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One possible explanation why Muc16 homozygous mutants were normal would be functional compensation by other mucin genes.
The impaired activity did not result from underexpression, since expression levels of the mutants were normal.
Pygo2 mutants developed to birth and showed limited abnormalities, while Pygo1 homozygous mutants were normal and fertile.
Whilst heterozygous single mutants were normal, Gas1 +/−; Cdon +/− mice had varying degrees of incisor fusion and premaxillary truncation but the palate remained intact (Fig. 3D F).
Importantly, head bristles, which are abnormal in Sb mutants, were normal in C765-Gal4 Sb-RNAi flindicativeative of the specific spatial targeting of the knock-down to the wing disc.
Similar(55)
Even though the ligand-binding function was abolished by these two mutations, the expression of these mutants was normal at the protein level.
Whereas rpm-1 mutants have disorganized presynaptic terminals at motorneuron NMJs, we find that presynaptic terminals at interneuron central synapses of rpm-1 mutants are normal at a gross level.
The retinas of Chrnb2−/− mutants are normal in appearance, but the increased expression of these genes may also be involved in the abnormal projection patterns of RGC to the LGN.
The motoneuron axonal morphology in both of these mutants is normal (Westerfield et al., 1990; Welsh et al., in press).
We found that CL occurred in let-60 lf) let-60 lfnder poor conditions, whereas the approach to sodiumutantside of the munders was normal [ 12].
The hindimb buds of the rescued Raldh2/Raldh3 mutants are normal, which has been interpreted as demonstrating that RA is not required for hindlimb outgrowth (Zhao et al., 2009).
Related(17)
genes were normal
variants were normal
mutants produced normal
mutants appeared normal
mutants displayed normal
mutants were recessive
mutants were stable
mutants showed normal
mutants exhibited normal
mutants formed normal
mutants had normal
mutants contained normal
mutants was normal
mutants conferred normal
mutants manifested normal
mutants were resistant
mutants were normalized
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