Similar to clp1Δ cells, lsk1Δ mutants appear normal under typical growth conditions, but display striking cytokinesis defects upon perturbation of the actomyosin ring.
Even though S310 is crucial for overall BicD phosphorylation levels, this seems not to affect BicD activity much, as Ser310 mutants appear normal, further arguing against critical roles of BicD phosphorylation on its activity.
By contrast, vulval development in ksr-1(n2526) single mutants appears normal.
Similar to clp1Δ cells, lsk1Δ mutants appear normal under typical growth conditions, but display severe cytokinesis defects upon perturbation of the cell division machinery.
In Hmx2, Hmx3 and Hmx2/3 null mice mutants cochlea gross structure appears unaffected, hearing capabilities in Hmx3 mutants appear normal but have not been directly tested in double mutants [ 24, 55].
While the growth of the ΔpdeH mutant appeared normal on CM agar plates (Table 2), the ΔpdeH mutant did undergo progressive autolysis of mycelia after prolonged incubation for at least 14 days (Figure 2, top panel).
In contrast, type I neuroblast clones of this double mutant appeared normal, as there was only one neuroblast per clone.
This analysis revealed a range of apparent karyotypes in the Cs– mutants: some appeared normal, whereas strain N84.06D harbored at least one extra, missized copy of nearly every chromosome.
R26floxneoWnt4 heterozygous and homozygous mutant mice appeared normal and were fertile.
Overall, the general health of mutant mice appeared normal in a specific-pathogen-free (SPF) animal facility.
