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But the regulated genes were normal and did not produce proteins that the immune system might recognize as abnormal.
BRAF and EGFR genes were normal in the PIK3Ca mutant lines.
The other genes were normal.
Domenga et al. suggested that Notch3 might act through a non-canonical pathway in VSMCs, because expression of classical Notch targets such as Hes genes were normal in Notch3 mutants (Domenga et al., 2004).
Consistent with our previous findings (11), the expression levels of the orexigenic Agrp and Npy genes were normal, whereas the expression level of the anorexigenic Pomc gene was significantly lower in Bbs2−/−, Bbs4−/− and Bbs6−/− mice compared with wild-type controls (Fig. 4A).
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Those genes are normal in most human narcoleptics but they still lack hypocretin, according to separate studies by Dr. Mignot's group and a team led by Jerome Siegel, a neuroscientist at the University of California, Los Angeles.
Activation of Jun N-terminal kinase or stress-activated kinase (JNK or SAPK) and mitogen-activated protein kinase (MAPK) and the induction of the transcription factor NF-ATc1 and egr-1 genes was normal.
In contrast, tumor suppressor genes are normal genes that must be inactivated or lost for tumor development.
The expression pattern of developmental genes is normal in His C mutant embryos.
9) In addition, can the authors exclude that the expressions of important developmental genes are normal at E6.5?
If sequencing of all three genes is normal for a Mendelian family, then screening for duplication of the APP gene should also be considered [ 65, 117].
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