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Exact(7)
The closed testing procedure was applied for multiplicity considerations of multiple primary endpoints.
All three primary outcomes were considered equivalent in importance and thus, the Type I error was corrected for these multiple primary endpoints.
However, because of the multiple primary endpoints (3 translations and 3 rotations to describe a 3-dimensional measuredn meatured at 4 follow-up moments) and the small sample size, we could not construct a mathematical model.
As trial outcomes are often classified based on results for reported primary endpoints, failure to accurately define a primary endpoint among a plurality of outcomes described or mentioning multiple primary endpoints constitutes a problem.
Last, we did not correct for multiple testing through application of the 'α spending function', since this correction primarily applies to multiple primary endpoints and since this would be extremely difficult considering the multitude of different statistical tests employed [ 69].
If no primary outcome is stated for a trial, or multiple primary endpoints are selected, results should be classified based on the statistical significance and direction of most (primary) outcomes (>50%).
Similar(53)
The focus of this study is a non-inferiority trial with multiple co-primary endpoints.
This study focuses on multiple cardiovascular risk factors as primary endpoints.
Bonferroni adjustment for multiple comparisons was performed for the primary endpoints, 6MWD and QoL parameters; P-values < 0.005 were considered significant.
Multiple recent clinical trials have failed on their primary endpoints indicating that there is a compelling need for validated biomarkers and outcome measures in fragile X.
In the case of several primary endpoints, for an "A" rating, the problem of multiple statistical testing had to be discussed or considered accordingly in the statistical methodology.
Related(20)
frequent primary endpoints
several primary endpoints
many primary endpoints
multiple correlated endpoints
multiple collaborative endpoints
multiple measured endpoints
multiple primary outcomes
multiple noncanonical endpoints
multiple secondary endpoints
multiple primary malignancies
multiple primary cancers
multiple primary networks
multiple primary protagonists
multiple functional endpoints
multiple unpredictable endpoints
multiple primary cultures
multiple primary links
multiple primary transceivers
multiple primary campaigns
multiple clinical endpoints
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