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In addition, while many primary endpoints (31%) in the summaries were measured against objective performance criteria, far fewer endpoints (12%) were held to these criteria in the published literature.
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[14], [15] We classified the type of primary endpoints as hard endpoints, intermediate endpoints and subjective endpoints.
Primary Endpoints.
Two primary endpoints are distinguished.
Both primary endpoints were met.
Primary endpoints occurred in 1804 (18.2%) patients.
The primary endpoints were safety profiles.
Primary endpoints were feasibility and toxicity.
The documentation of longitudinal profiles for the primary endpoint offers many advantages.
Although overall survival is still considered as the primary objective and the primary endpoint in many studies, most clinical trials now integrate HRQoL as an endpoint in order to investigate the clinical benefit for the patient.
Treatment with nintedanib was associated with significant improvements in the primary endpoint and many secondary outcomes in the INPULSIS-1 and INPULSIS-2 trials, suggesting that this agent is a promising treatment for IPF.
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