Exact(2)
For this, it was tested across multiple functional endpoints, reflective of the range of known signaling pathways FFA2 is able to regulate (27).
Treatment of endothelial cells with agents that block VEGF receptor signal generation (neutralizing antibodies), reduce receptor level (siRNA), or inhibit receptor kinase activity (SU5614) all result in enhanced TNF-α sensitivity, as determined using multiple functional endpoints.
Similar(6)
Our findings highlight the need to integrate multiple, diverse, and functional endpoints to more appropriately discern the effects of Hsp90 inhibition upon HIF function.
The choice of suitable functional endpoints in glaucoma trials is also a critical consideration.
Nodes with multiple functional links represent "functional hubs".
This notion of increased NO bioavailability was extrapolated from functional endpoints, such as vessel relaxation.
A larger study with functional endpoints is needed to confirm our findings.
Both the Expedition 1 and 2 studies did not meet co-primary cognitive and functional endpoints.
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