Our case is instructive of the need to pay attention to the possibility of multiple primary cancers in that situation.
Therefore, DCF may be a suitable first-line therapy for multiple primary cancers of the esophagus and other organs with distant metastasis.
We should also suspect the possibility of multiple primary cancers, even if the patient has a history of cancer that is likely to cause metastatic lesions.
Head and neck squamous cell carcinoma and gastric adenocarcinoma are most frequently observed as multiple primary cancers of other organs in patients with esophageal cancer [2, 3].
Natugoe et al. [1] reported that double cancer of the esophagus and breast was observed in only one patient in 157 cases of multiple primary cancers with esophageal squamous cell carcinoma, including synchronous and metachronous types.
Coding of multiple primary cancers followed a common set of rules proposed by the International Association of Cancer Registries and the IARC [26].
The incidence of multiple primary cancers has recently increased.
Patients were excluded when they had borderline tumors, multiple primary cancers, or non-epithelial tumors.
Patients with multiple primary cancers were always excluded from trial entry.
The earliest date of diagnosis was used in cases with multiple primary cancers at different times.
The occurrence of multiple primary cancers may be attributed to shared aetiological factors [ 3, 6].
