Sentence examples for multiple methylation defects from inspiring English sources

Cis-acting variations of the DMRs are not involved in the multiple methylation defects.

Thirty-four percent of KvDMR1 loss of methylation patients and 30% of H19DMR gain of methylation patients showed multiple methylation defects.

To date, multiple methylation defects have been reported in Beckwith Wiedemann syndrome patients with epimutations; however, limited numbers of DMRs have been analyzed.

The susceptibility of DMRs to aberrant methylation, alteration of gene expression due to aberrant methylation, and causative factors for multiple methylation defects remain undetermined.

Overall, there was no difference between the average β values of BS-treated blood samples from patients with KOS14 and those from the normal control, indicating that multiple methylation defects were not observed in these three patients.

Hypomethylation at multiple imprinted DMRs has been reported in patients with transient neonatal diabetes mellitus type 1, and the same phenomenon, referred to as multiple methylation defects (MMDs), has been reported in BWS patients with KvDMR1-LO M KvDMR1-LO M

However, no single individual in our population had disruption of DNA methylation at multiple DMRs, thus excluding an environmental or genetic predisposition to imprinted methylation defects in this sample set.

The observations hint that methylation defects of sperm DNA may play a crucial role in determining the fertility of breeding bulls.

Beckwith-Wiedemann and Silver-Russell patients with IC1 methylation defects have similar methylation defects at the IGF2 DMR0, consistent with IC1 regulating methylation at IGF2 in cis.

The crystal structure provides a structural explanation for the observed trans-complementation of MTases with different methylation defects.

A factor here represents a combined effect from multiple methylation sites with various levels of contribution.