Sentence examples for multiple methylation states from inspiring English sources
To further characterize the histone modifications in different non-genic regions, we compared the multiple methylation states of individual residues in each region.
By using two dependent Hidden Markov Models (HMM) (MacDonald and Zucchini, 1997), which can be fine tuned to approximate any WGBS dataset, we are able to simulate any genome-wide datasets taking into account spatial co-dependence, multiple methylation states (such as those in CpG islands or shores), read depth and number of replicate experiments.
A factor here represents a combined effect from multiple methylation sites with various levels of contribution.
Thus, exposure of female mice to cocaine during pregnancy resulted in multiple alterations in the methylation states of offspring DNA, and some of these cocaine-related effects could persist through at least the prepubertal period of 30 days postnatum.
To address this, our approach explicitly models the existence of statistical dependencies between methylation states from multiple related cell types.
In the case of DNA methylation, many studies use the aggregation of methylation states at multiple CpG (CG) sites across many regions to compensate for the sparsity of signal at any specific location relative to a boundary.
SAM then serves as a source of methyl groups for multiple methylation reactions, including the methylation of DNA.
> The search toolkits in the homepage of DevMouse can be used to acquire the methylation states for any given genes/regions of interest across multiple developmental stages.
The use of multiple tissues from 30 individuals allowed us to evaluate variation of DNA methylation states across tissues and individuals.
The MeDIP procedure combined with CGI microarray technology enabled us to reliably and efficiently profile the methylation states of a wide range of CpG islands in multiple samples.
Thus, it is critical to find factors that regulate DNA methylation states in reprogramming.
