Sentence examples for multiple methylation events from inspiring English sources

Involvement of the cobalamin cofactor might mechanistically rationalize multiple methylation events occurring at the C8 position; however, a detailed investigation of the mechanism currently remains lacking.

Strikingly, for either mark, an exceedingly small subset of marked genes is perturbed upon loss of respective enzyme, suggesting either existence of multiple redundant silencing mechanisms or these methylation events being a secondary consequence of repression.

This approach combines the power of multiplex and real-time PCR to detect methylation events simultaneously at multiple loci, and increases the sensitivity of the approach to 1 in 10 107 copies of DNA [ 20].

SAM then serves as a source of methyl groups for multiple methylation reactions, including the methylation of DNA.

A factor here represents a combined effect from multiple methylation sites with various levels of contribution.

It is possible that the methylation changes reflected a generalized CpG island methylator (CIMP) phenotype where a majority of methylation events may represent "passenger" methylation.

Using this analysis to assess members of the S100 gene family for evidence of methylation-dependent regulation, we have successfully identified four S100 family members which showed upregulation in multiple cell lines following demethylation treatment, and were subsequently shown to be associated with specific DNA methylation events.

It is also not trivial to assign unambiguously dynamic methylation events to specific PMTs given their potential redundancy.

The methylation pattern analysis showed that gene methylation does not occur stochastically and concordant methylation events seem to take place in the same primary MCL.

In this present report we address the relationship between multiple genomic parameters associated with breast cancer metastasis and progression, by hypothesizing that the complex chromosomal alterations in cancer cells may complicate the interpretation of the promoter-specific methylation events responsible for gene-specific expression changes.

We observed that gene methylation events tended to occur in the same primary MCL (Figure 5A).