Sentence examples for multiple methylation modules from inspiring English sources

Multiple methylation modules exhibit significant enrichment.

GO enrichment analysis of methylation modules revealed multiple significantly enriched categories (Table  5).

For example, eigengenes of methylation modules 2 and 7 (both enriched in immune system/response terms) are strongly correlated with multiple expression eigengenes such as ME 7 (enriched in immune system process), 12 (ribosome), 15 (intracellular signal transduction), 19 (ribosome), and 22 (no significant enrichment).

The sub-modules of the DNA methylation modules and chromatin modification modules were considered as the candidate interplay modules.

M and H are defined as the genes counts of the DNA methylation modules and chromatin modification modules, respectively.

Additional file 6; Table  2 provides a brief overview of the methylation modules along with 10 top hub genes (genes with highest module membership) in each module.

For easier interpretation of the relationships between expression and methylation modules, we use the same module labels for modules that show significant overlap.

A natural question is whether the expression and methylation modules are related.

In the 42 T2D-related DNA methylation modules and 21 T2D-related chromatin modification modules, the interplay modules of DNA methylation and chromatin modifications for T2D were detected by the cumulative hypergeometric test method (see Methods for details).

Thirty-four percent of KvDMR1 loss of methylation patients and 30% of H19DMR gain of methylation patients showed multiple methylation defects.

In summary, we observed multiple strong correlations between expression and methylation module eigengenes.