Sentence examples for multiple functional variants from inspiring English sources

The presence of multiple functional variants of traits involved in activities such as feeding, reproduction, or the defense against predators is relatively uncommon within animal species.

Alternative splicing is a tightly regulated process that generates multiple functional variants from individual genes, thus enhancing protein diversity.

Some results suggest that multiple functional variants from genes in neurodevelopmental pathways contribute to development of SZ [ 8], while the biological mechanism is undefined.

While this SNP is not a strong proxy for a functional variant, there are multiple functional variants in weaker linkage disequilibrium that may be of interest.

This evidence together indicated that multiple functional variants of the Ras/PKA pathway are present in natural yeast populations, which either independently or in combination contributed to their adaptation in diverse conditions.

The authors describe the concept of using dose response curves based on multiple functional variants in genes of pharmaceutical interest in order to prioritize molecular targets in drug development.

In the majority of cases (19/23 genes under balancing selection), less than 50% of the genotypes were impacted by frame-shifts or large effect SNPs, with multiple functional protein variants still present.

We have developed a system that combines a unique collection of data from multiple functional annotation categories to prioritise variants by predicted function.

An advantage of the methodology presented here is that ExomeWalker quickly shows whether there are candidate genes with both predicted pathogenic variants and multiple functional associations with other genes in the same disease-gene family.

Thus, it remained unclear whether the associated markers all reflect the same functional variation or, more likely, multiple functionally important variants are present in a large region encompassing DAOA/G72 [ 5].

Post-GWAS fine-mapping studies are challenging, but the use of multiple tools can assist in identifying candidate functional variants in at least some cases.