The 45-kDa fragment has multiple functional advantages in processes such as cell attachment, migration, and spreading, through binding to a9b1 and a4b11.
The Nrxs and NLs both contain an extracellular domain that participates in pre- and post-synaptic interactions and an intracellular domain that is involved in multiple functional interactions and regulation processes (Südhof, 2008; Lisé and El-Husseini, 2006; Craig and Kang, 2007).
We used multiple functional ontologies for enrichment analysis: GO processes, GG processes, disease categories and canonical pathway maps.
Although the characteristic property of (TG/CA)n repeats exhibiting length polymorphism has been widely used in genetic mapping [ 6], a growing body of evidence accumulating over several years point to their multiple functional roles in various biological processes.
This co-expression of multiple genes is anticipated, given that functional processes and molecular pathways in an organism involve a highly organized interplay between multiple genes.
This multilayer process creates multiple functional versions of the same genome, or epigenomes that have that capacity to interpret the genomic information in a context-dependent manner.
In this article we considered four hypotheses regarding the nature of the selective forces that favor a large protein size: i) Larger proteins are involved in multiple biological processes, therefore requiring multiple functional domains.
Moreover, these inter-module mediators appear to be responsible for linking, and possibly coordinating, the activities of multiple network modules associated with diverse functional processes and cellular localizations.
Alternative splicing is a tightly regulated process that generates multiple functional variants from individual genes, thus enhancing protein diversity.
