Sentence examples for multiple causal variants from inspiring English sources

One lesser-known aspect of complex traits is the extent of allelic heterogeneity (AH) arising from multiple causal variants at a locus.

How large should our study be to capture multiple causal variants?

Such an approach is not applicable to deal with the discovery of multiple causal variants, since we then have to consider the impact of multiple testing problem.

We found multiple tSNPs spanning the entire length of the gene and several haplotypes to be associated with the traits of interest, suggesting there may be multiple causal variants across the WNK1 locus.

Allelic heterogeneity refers to a situation where multiple causal variants of differing frequency and effect size exist within a gene.

Single SNP analysis may not be adequate for identifying multiple causal variants and predicting risk of disease [ 14].

We examined the effect of averaging over either all two SNP or all three SNP models in the context of the above multiple causal variant simulations.

The possible presence of different or multiple causal variant(s) in different populations may account for the lack of correlation for some of the index SNPs between populations, although false positives in local transferability analysis could not be excluded.

Alternatively, if there exist multiple common causal variants, then dense genotyping should enable the multiple SNPs required to describe the SNP-trait associations to be identified, and this test will be more widely applicable, with the caveat that all causal variants must operate in the same manner for the data to appear consistent with the null.

Nariai, N., Greenwald, W. W., DeBoever, C., Li, H. & Frazer, K. A. Efficient prioritization of multiple causal eQTL variants via sparse polygenic modeling.

All of these genes contained multiple causal rare variants with a moderate or high effect size.