Sentence examples for many functional variants from inspiring English sources

From the R-GECO1 librarylibrary (strategy 3), we identified many functional variants, but none with substantially higher Kd values than R-GECO1.

Despite the fact that we have discovered many functional pharmacogene variants, the uptake of pharmacogenomic testing in the clinic has been slow.

There is increasing evidence that many of the functional variants that underlie associations in GWA studies exert their effects through gene regulation rather than changing gene products.

We define four high-level categories of variants that are of particular interest for many functional studies: 1. Putative LoF variants: variants that are likely to cause a gene product to be subject to nonsense-mediated decay and result in lost (or impaired) function of the gene.

These results also provide many functional hypotheses of genetic variants in re-defined candidates that may influence breast cancer susceptibility.

All possible single nucleotide variants CADD scores were downloaded and provide a score to prioritize functional, deleterious and pathogenic variants across many functional categories, effect sizes and genetic architectures was unmatched by any current single-annotation method.

This example also illustrates the extreme complexity and challenge in finding causal and functional variants in the many recently identified risk loci.

Across the wider genome, many 'neutral' (unannotated) variants may be true functional variants that are not reported because (i) they haven't been tested against a relevant phenotype or (ii) their effects are subtle and haven't been detected.

This approach determined that surrogate SNPs for many of the cancer-associated SNPs are functional variants with a likely role in regulation; these should be prioritized for functional assays.

It is important to note that many polymorphisms can be simply in linkage disequilibrium with truly functional variants, and fundamental investigations are needed to determine if they are merely markers of association or indeed causal variants.

As a group, these variants would be likely to be associated with changes across many functional annotation categories, thus they can be identified by a range of functional annotation weightings.