Survivin is an essential component of multiple functional protein complexes in cancer cells.
It is a multiple functional protein as the N-terminal domain1 45 possesses antipathogenic activities such as antibacterial, antihelminthic, and antiviral competencies [ 15– 17].
Recent examination of proteins in model bovine chromaffin secretory vesicles revealed multiple functional protein categories that participate in secretory vesicle production of neuropeptides and catecholamines for cell cell communication (Fig. 7) (49, 49).
In the majority of cases (19/23 genes under balancing selection), less than 50% of the genotypes were impacted by frame-shifts or large effect SNPs, with multiple functional protein variants still present.
BRCA1 has been described as a multiple-functional protein, which plays an important role in cell cycle control and apoptosis besides its function in genomic integrity [38].
In conclusion, these data show that cocktail immunization targeting multiple (functional) salivary proteins resulted in impaired tick feeding, while immunizations with individual proteins did not have an effect.
These proteins fell into multiple functional categories including protein synthesis, energy metabolism, and protein fate (Table S5).
The mice will be a welcome new tool for studying molecular events regulating synapse dynamics in the adult brain as proteins of choice can be expressed in a reproducible manner, allowing direct comparison of neurons expressing multiple fluorescent and/or functional proteins.
The 72 upregulated and 12 downregulated candidate genes described above were categorized into multiple functional classes of proteins (supplementary material Table S1).
