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Most persons undergo sequential infections with multiple antigenic variants of human influenza subtype H1N1 and H3N2 viruses throughout their lives.
The detection of multiple antigenic variants in the sequence of the major pilin after 2 days of biofilm growth highlights this (Kouzel et al., 2015).
In support of this finding, a more recent statistical analysis has shown that multiple antigenic variants co-circulate (Strelkowa and Lässig, 2012).
(B ) Simulated epidemiological dynamics showing co-circulation of multiple antigenic variants and sustained prevalence levels over time for this same simulation.
Thus, HVR1 heterogeneity could facilitate treatment failure since coexistence of multiple antigenic variants could increase the probability of positive selection of those effectively evading immune pressure induced by treatment [ 15, 16].
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The presence of multiple copies of these genes allows the generation of antigenic variants within a single genome, greatly facilitating immune escape of the parasite.
The possibility of multiple antigenic conformations or intermolecular epitopes cannot be ruled out when considering surface antigen structure.
multiple antigenic peptide.
The identification of antigenic sites of H9 is important for monitoring antigenic variants and developing effective vaccines.
These prototypes represented each of the main antigenic variants of hMPV, because antigenic variability could have implications for vaccine development.
Tam developed the multiple antigenic peptide (MAP) system to improve the poor immunogenicity of subunit peptide vaccines [23].
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numerous antigenic variants
multiple antigenic strains
multiple antigenic conformations
multiple antigenic types
multiple antigenic proteins
multiple parental variants
multiple antigenic challenges
multiple antigenic differences
multiple viral variants
multiple antigenic epitopes
multiple antigenic moieties
multiple antigenic targets
multiple antigenic phenotypes
multiple antigenic variations
multiple distinct variants
multiple causal variants
multiple antigenic modules
multiple antigenic molecules
multiple deleterious variants
multiple antigenic determinants
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