Immunity-driven balancing selection pressure on parasite invasion proteins often results in the presence of multiple, antigenically distinct, variants within a population, leading to variant-specific immune responses.
Single cell sequencing studies that identified multiple genetically distinct variants within human tumours clearly demonstrate the heterogeneous nature of human tumours.
The data support the alternative hypothesis of a multiple rare variant model, possibly consisting in distinct variants in different populations, influencing VEGF serum levels.
Combined, these studies unequivocally show that genetically distinct variants of tumour cells exist within individual tumours in multiple tumour types.
In this approach researchers actively gather multiple distinct sources of evidence to assess a given factor (e.g., variant, gene, exposure, or pathway) in the pathophysiology of interest.
Furthermore, our results indicate geographic clustering of distinct variants within and between states and reinforce previous evidence supporting the likelihood of multiple introductions of virus into the state of Texas (13).
Allophone, one of the phonetically distinct variants of a phoneme.
Distinct variants of the viruses have been described.
Finally, there are two distinct variants of this scenario: λ=1 for ∥-attack; λ=3 for ∴-attack.
Single gene segments can contribute to multiple, distinct somatic loci.
