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Simultaneous infection with multiple antigenic strains of O. tsutsugamushi was detected in an individual mite, Leptotrombidium arenicola (9 ), a probable vector of scrub typhus.
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multiple antigenic peptide.
Tam developed the multiple antigenic peptide (MAP) system to improve the poor immunogenicity of subunit peptide vaccines [23].
These were synthesized in combination as three multiple antigenic peptides (MAPs).
Tam developed the multiple antigenic peptide (MAP) system using a non-immunogenic lysine-based dendritic scaffold to improve the immunogenicity of subunit peptide vaccines (Tam, 1988).
αβ T-cell receptors (TCRs) recognize multiple antigenic peptides bound and presented by major histocompatibility complex molecules.
In addition to Fimbriae 2 and 3, Prn, FHA and PT, which have multiple antigenic variations, BipA and OmpQ also have two different antigenic variations.
Sw/Jilin/19/07 had two variations at the antigenic sites A and B, while Sw/Jilin/5/07 and Sw/Jilin/37/08 accumulated four variations at the antigenic sites A and B. The gradual mutations of HA might generate new antigenic strains.
Both these scenarios lead to coexistence of multiple antigenic phenotypes.
The new antigenic strain invades and successfully establishes, while excluding the resident strain, characteristic of a successful antigenic cluster transition.
(C ) Large antigenic mutants arising in good genetic backgrounds can successfully establish and exclude the resident antigenic strain, resulting in an antigenic cluster transition.
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