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Buoyed by such preliminary evidence, a number of clinical trials are now underway designed to explore the efficacy of multiple antigenic moieties, many revealed through microarray analysis, which may prove of value in breast cancers of different histological types and or metastatic risk [ 34].
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The antigen recognition pattern of immunoglobulin M (IgM) could, when directed against protein antigens, provide an indication of the antigenic moieties triggering new B cells.
The possibility of multiple antigenic conformations or intermolecular epitopes cannot be ruled out when considering surface antigen structure.
multiple antigenic peptide.
This could then result in an autoimmune response, directed at tissues bearing these modified antigenic moieties.
Tam developed the multiple antigenic peptide (MAP) system to improve the poor immunogenicity of subunit peptide vaccines [23].
These were synthesized in combination as three multiple antigenic peptides (MAPs).
αβ T-cell receptors (TCRs) recognize multiple antigenic peptides bound and presented by major histocompatibility complex molecules.
Tam developed the multiple antigenic peptide (MAP) system using a non-immunogenic lysine-based dendritic scaffold to improve the immunogenicity of subunit peptide vaccines (Tam, 1988).
Spleen cells from calpain multiple antigenic peptide (MAP -immunized BALB/c MAP -immunizedIFNγ upon stimulation with MAP or soluBALB/crmicetigen producedIFNγ(SWAP).
Therefore, the dendritic tandem multiple antigenic hTERT epitope peptides combined with MDCs may represent a powerful, broad-spectrum anti-tumor vaccine.
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