Sentence examples for mouse models recapitulate from inspiring English sources

Several mouse models recapitulate the cardinal features of human oligodendrogliomas (ODGs) (Holland, 2001a, 2001b, 2001c; Betsholtz, 2004; Shih et al, 2004; Salpietro and Holland, 2005).

However, relatively little is known about whether RTT mouse models recapitulate the unique features of progression, regression and stabilization that define the human disease.

Having defined distinctive gene expression patterns among the PCT subtypes as well as between PCTs and BCLs, we next sought to examine how well our mouse models recapitulate human phenotypes as measured by relative similarities of gene expression patterns.

Although induction of prostaglandin E2 pathway promotes gastric tumors in mice in cooperation with deregulated Wnt or BMP signalings, it has remained unresolved whether the gastric tumor mouse models recapitulate either of human gastric cancer type.

Although, Mecp2 mutant mouse models recapitulate key characteristics associated with RTT patients including an initial phase of apparently normal development followed by severe neurodevelopmental dysfunction, there is evidence that mouse models are an underrepresentation of the human condition (19– 219.

Although transgenic mice demonstrate some abnormalities in behavior in specific experimental conditions (Clapcote et al., 2007; Hikida et al., 2007; Barros et al., 2009), it is difficult to determine how well these mouse models recapitulate the human condition because it is difficult to assess complex phenotypes such as hallucinations and delusions in mice.

Several mouse models recapitulating features of AD pathology have been used to investigate whether the process of neurogenesis is altered in the disease and whether it contributes to cognitive impairments (see refs in [26]).

Genetically engineered mouse models recapitulating specific pathway abnormalities such as double transgenic c-myc/TGFα mice might be more successful at predicting clinical response.

Excessive Hh signalling via overexpressed ligands, loss of Ptch, expression of mutant Smo or overexpression of Gli transcription factors in mouse models recapitulates the human disease (reviewed by Kasper et al., 2012 ).

Given the BMI1-high/ TP53-low molecular signature associated with Group 4 MB, and the resultant phenotype observed in mouse models recapitulating this genotype, we characterized the transcriptional network associated with BMI1 expression in this molecular subgroup.

Taken together, these data show that the mouse models recapitulated the findings in human liver diseases, and FGF21 expression is significantly induced in hepatocytes in response to perturbation of liver functional capacity by liver damage (viral infection, cirrhosis, steatosis and toxins), partial resection and carcinogenic transformation (HCC, clear cell HCC and cholangiocellular carcinoma).