For that reason, exosomes were injected in injured mouse hearts and could recapitulate the regenerative effects of CDC transplantation, while blocking of exosome production by CDCs attenuated these effects.
Mouse models that overexpress GRK2 in the heart recapitulate much of this phenotype.
A compensatory effect was also observed in the mdx+/− mice (mdx heterozygous mice recapitulate DMD asymptomatic carriers).
Similarly MmURE2 transgenic mouse lines recapitulate endogenous Dlx1/Dlx2 expression in this domain [ 18].
These results imply that R120G TG mice can recapitulate the DRM pathology, resulting in eventual heart failure and death as described previously [3], [14].
Genetically engineered mouse models can recapitulate rare variants, displaying some behavioral defects associated with schizophrenia; however, these mouse models cannot recapitulate the full genetic architecture underlying the disorder.
This observation could explain why no sufficient ASPM-deletion mouse models that recapitulate microcephaly phenotypes have been developed.
As a model, the Fabry mouse appears to recapitulate early, rather than later effects of the disease process.
Such a mouse should faithfully recapitulate human disease symptoms; this is particularly true for point mutations.
Natural and experimental helicobacter infections in mice reproducibly recapitulate important features of human disease.
