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Why do these mouse models differ?
As markers indicating metastatic spread in syngenic mouse models differ significantly from those in man, this study aimed to develop a human melanoma xenograft mouse model that reflects the clinical situation.
Many of the AD mouse models differ in the site of the mutation in APP, or in the number of APP mutations in one mouse, or the addition of mutations in PS1 or tau.
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The above results indicated that mouse models differed with respect to immune-associated gene expression patterns (Figures 6 and S6) and also with respect to their microarray-based inflammation profiles (Figure 9).
With respect to motor function, the mouse model differs from the human disorder.
It is also not clear whether the expression of HD-like symptoms at the pre-motor stage in this mouse model differs between the two sexes.
With respect to the dramatic outburst of aberrant DNA methylation in the late stage, our AML-like mouse model differs from a recently reported chronic lymphocytic leukemia-like mouse model, where early DNA methylation events are followed by a gradual increase of aberrantly hypermethylated genomic regions over time [ 54].
Methods: We used two congenic mouse models that differ at the Ahr gene and encode AHRs with a 10-fold difference in signaling activity.
The discrepancy in results may be explained partly by the fact that the rat and mouse mammary gland tumor models differ; the rat models are carcinogen-induced and the mouse models oncogene-driven.
Two strains of mice, C57Bl6 and Balb/c, were used in order to obtain generalizable data for mouse models that differ slightly in disease phenotype [12].
Studies of human NK cells and their role in tumor suppression have largely been restricted to in vitro experiments which lack the complexity of whole organisms, or mouse models which differ significantly from humans.
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