Sentence examples for vitro models recapitulate from inspiring English sources

In vitro models recapitulate tissue-specific microenvironments of the human body in an experimental setting to study cell functions and responses in a holistic approach and to develop improved therapeutics.

Although the natural process of carcinogenesis is highly complex and specific to each cell type and/or carcinogenic insult, in vitro models recapitulate the basic events necessary for cellular transformation.

Therefore, this 3D in vitro model recapitulates the p16INK4a-associated secretory phenotype characterizing senescent-like chondrocytes found in OA cartilage.

In particular, as iPS cells represent an early stage of disease, the establishment of in vitro differentiation models recapitulating specific cell-type differentiation would be relevant for dissecting pathogenetic events responsible for disease initiation and progression.

The following chapter aims to introduce and discuss 3D cell-based in vitro models that recapitulate both the architecture and multicellular complexity of an organ/tumor in vivo but at the same time accommodate systematic experimental intervention.

To measure the effect of LCN7 overexpression on these processes, we used a series of in vitro models that recapitulate these angiogenic activities.

The growing appreciation that cellular and molecular mechanisms are controlled by the microenvironment in which they operate in vitro models seldom recapitulate in vivo behavior indicates a need to simultaneously monitor biological processes at various scales non-invasively.

In vitro models cannot recapitulate such complex end points.

Thus, it is critical to ensure that in vitro models adequately recapitulate the main metabolic processes for Cr VI) in tissues.

In vitro models that recapitulate the liver stages of human malaria are needed to identify compounds that have potential antimalarial activity, but most of these models are dependent on cell lines (Gego et al., 2006; Meister et al., 2011) due to limitations in in vitro culture of primary adult hepatocytes.

In spite of this wealth of evidence supporting a role for altered tau splicing in disease pathogenesis, the molecular mechanisms linking tau splicing to disease remain poorly understood, in part due to the lack of in vitro models that recapitulate the diversity of tau isoforms seen in the adult human CNS.