We have included a figure supplement to demonstrate that our Slc17a7-IRES-Cre mouse line recapitulates the expression of the Slc17a7 gene.
We have established an E-cadherin/p53 double conditional knockout (DCKO) mouse line that recapitulates human DGC morphologically and molecularly.
Forty-two celinesnes recapitulating mammary carcinoma heterogeneity were profiled for all- trans retinoic acid (ATRA) sensitivity.
Ins2 knock-in mouse lines have also been generated [ 25], but are similarly expected to recapitulate endogenous expression and result in ectopic expression in brain.
The Fmr1-mouse line does not recapitulate all of the main core and secondary ASD symptoms, but still can be useful to elucidate the neurobiological mechanisms underlying specific ASD-like endophenotypes.
Therefore, the tert-deficient zebrafish line recapitulates the mechanisms of age in telomerase-deficient mice and individuals with DC (Armanios et al., 2005; Knudson et al., 2005; Vulliamy et al., 2004).
We demonstrate here that strain-related Sost down-regulation in cells of the human osteoblastic Saos2 cell line recapitulates in vitro, in terms of time, that stimulated in osteocytes by loading of the mouse tibia in vivo [9].
Globally, the hoxb4a-YFP enhancer trap line recapitulated the endogenous expression in r7 8 (Fig. 1).
A compensatory effect was also observed in the mdx+/− mice (mdx heterozygous mice recapitulate DMD asymptomatic carriers).
The reduced viability and blood phenotype (described later) of this S1PL−/− gene-trap line was recapitulated in another S1PL knockout mouse line generated by homologous recombination in which exons 7 8 were replaced by a cre-lox selection cassette (data not shown).
