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Few mouse models exist for the study of tumor suppressor systems in PTC.
Several mouse models exist for hematopoietic malignancies which correspond to distinct tumor entities, including B or T cell lymphomas or myeloid leukemias [1], [2].
As atherosclerosis does not develop spontaneously in rodents, several transgenic mouse models exist that allow study of atherogenesis when fed western-type diet [20].
Moreover, transgenic mouse models exist where a reporter gene, such as green fluorescent protein (GFP), marks a specific phenotype of neurons and these could be used to ferret out the pharmacology of the vlPAG neurons.
Gene targeted mouse models exist for all the class I PI3K catalytic and regulatory subunits and, together with the availability of isoform specific inhibitors, have greatly enhanced our understanding of PI3K signalling.
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Patients with an absence of Rab27a have Griscelli syndrome type II and a naturally occurring mouse model exists (the ashen mouse).
While a Lamb3 mouse model exists, recessive mutants died within 24 h of birth and no examination of teeth was performed.
No current mouse model exists for an in vivo Malassezia infection; hence, the authors used an alternative system whereby the fungus was injected intraperitoneally.
If a mouse model exists that closely reproduces the human disease, then perhaps this would be the ideal system to use; the phenotypic influence of a SNP and/or putative causal target gene may be more consequential in a living organism than in a short-term cell culture assay.
Although many sophisticated mice APP models exist, none comprises all features of AD cellular and behavioural pathology.
Several other mutant SOD1 mouse models now exist that also model ALS; these models all have slightly different pathologies, including time to onset of symptoms and death (e.g. Bruijn et al., 1997; Jonsson et al., 2006; Nicholson et al., 2000).
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