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It is estimated that 40% of all transcription units in human and mouse genomes exist in cis-antisense co-expressed pairs [44], [45] and there is correlative evidence for a regulatory function of antisense in animals and plants [46], [47].
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Eukaryotic genomes exist in highly packaged structures called chromatin.
For some of these taxa a number of well annotated genomes and genes exist, human and mouse genomes and transcriptomes being especially useful, with the full-length mRNAs that enabled reconstructions of the complete gene structures in these species [ 34, 35].
In a separate analysis Kumar et al. have estimated that there exist 529 conserved segments between the human and mouse genomes [ 6].
Biologists believe the mouse genome will be essential to interpreting the human genome.
Celera said its mouse genome would be available only to subscribers to its database.
Although the variation information gained from the mouse genomes in this project has been essential, difficulties in producing reliable sequence in regions where structural variation exists continues to prove problematic.
While the human and mouse genomes contain comparable numbers of L1 elements, several phylogenetic and L1Xplore analyses in the mouse genome suggest that 1,500 3,000 active L1 elements currently exist and that they are still expanding in the genome.
Using a test that compares mutations on the human and mouse genomes, and that takes into account those which cause changes in a protein, the authors of the analysis found that some 5percentt of each genome is under selective pressure.
The unique reads were analyzed and mapped to the human and mouse genomes (reference genomes hg19 and mm9, respectively).
But some experts feel that less than 60percentt of the genome exists in haplotypes.
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