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In addition, mouse iPSCs exist in a more primitive 'naïve' pluripotent state compared with the more primed state of human iPSCs (Rossant, 2015).
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We next tested whether the phenotypes observed in mouse iPSCs could also be detected in human HD patient-derived iPSCs.
These results indicated that 3D collagen scaffolds could enhance cell proliferation and stemness of mouse iPSCs.
(A) Scanning images of mouse iPSCs on 2D plates (left) and in 3D scaffolds (right).
(B) Cell viability analysis of mouse iPSCs on 2D plates and in 3D scaffolds.
We carried out the first membrane proteomic profiling of mouse iPSCs, in comparison with ESCs and adult mouse tail tip fibroblasts (TTFs) from which iPSCs were generated.
In the current study we characterized and demonstrated the pluripotency and osteogenic differentiation of mouse iPSCs.
On the other hand, differentiated tissues derived from human or mouse iPSCs can readily tolerate temporary MYC inactivation.
Furthermore, it is possible that the difference in telomere elongation in mouse IPSCs relative to human IPSCs is a simple function of average telomere length.
Currently the genome of iPSCs is being scrutinized, and recent work shows that iPSCs contain chromosomal aberrations, such as chromosome 12 duplications in human iPSCs [13] and aberrantly silenced genes on chromosome 12qF1 in mouse iPSCs [11].
It has been verified that mouse iPSCs can form functional spermatozoa [ 46, 47].
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