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For RDEB, at least two murine models exist, one with no expression of basement membrane type VII collagen (C7) [ 4], and one with approximately 10% wild-type expression of C7 [ 5].
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Similarly, a few animal models exist in which viral infection triggers CNS demyelination such as Theiler's murine encephalomyelitis virus (TMEV) [ 16, 17] and neurotropic strains of mouse hepatitis virus (MHV) [ 18– 218.
Nevertheless, some models exist.
Various CCA animal models exist including carcinogen-based models in which animals develop CCA after exposure to a carcinogen, genetically engineered mouse models in which genetic changes are induced in mice leading to CCA, murine syngeneic orthotopic models, as well as xenograft tumors derived from xenotransplantation of CCA cells, organoids, and patient-derived tissue.
Various models exist across health care models.
Several conceptual models exist [ 30- 32].
Still, a number of positive models exist.
Many good, insulated models exist.
Few soft-tissue murine models of leiomyosarcoma exist.
Over 50 such clone models existed.
The benefits of using mice are that a murine model of narcolepsy exists and it provides a valuable tool to identify the circuitry underlying the disease.
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