In conclusion, the characterization of the RNF5 transgenic and KO mouse models establishes an undisclosed link between impaired ER stress response and the early changes in degenerative myopathies, shown here for sIBM, while offering a novel model for studying the complex function of the ER in global muscle physiology.
To identify direct transcriptional targets of TH and genes containing TREs, we produced global gene expression profiles in hypothyroid and hyperthyroid mouse models established by short-term exposure to MMI and perchlorate and/or TH injection.
Here, an inducible KrasG12D-driven PDAC mouse model establishes that advanced PDAC remains strictly dependent on KrasG12D expression.
CHD1L transgenic mouse model established in this study provides a very useful tool for investigating CHD1L function and role in cancer development.
Potential in vivo nephrotoxic effect of the polymyxins was evaluated in a mouse model established in our group.
In our previous study, we found that hippocampal neurogenesis is significantly decreased in a TD mouse model established by feeding mice with a thiamine-depleted diet.
A unique metastasis mouse model established in our laboratory represents a late stage of metastasis development in human HNSCC (Zhang et al, 2002).
Using another immunocompetent mouse model, established by intravenous inoculation of BCM, DP42, or ATLN MM cells into syngeneic mice, MDSC accumulated in BM as early as 1 week after tumor inoculation.
Remarkably, a more contemporary report from the Wolf laboratory in a hepatic CPR deletion mouse model established that b5 and b5 reductase can act as efficient CYP electron donors, without the need of CPR.
The cFSGS mice model, established by cell cycle inhibitor p21 knockout, manifested progressive loss of podocytes with collapsed capillary loop and hyperplastic epithelial cells which were negative for WT-1 and nestin (both podocyte specific markers) but positive for PECs markers [ 27].
