Sentence examples for modulation of therapeutic from inspiring English sources

In this review article we will discuss the general protumorigenic effects of acidosis, the role of tumor acidosis in the modulation of therapeutic efficacy and potential strategies to overcome pH-dependent therapy-resistance.

Short, single stranded, unformulated LNA oligonucleotides hold significant promise as drugs for potent, safe and selective modulation of therapeutic interesting mRNA and miRNA targets.

Integrative approaches that examine gene expression in the genomic and proteomic context may lead to the discovery of previously unconsidered mechanisms for the modulation of therapeutic responses.

The induction of programmed cell death or apoptosis is both a desired outcome of cancer therapy and a potential target allowing imaging and modulation of therapeutic effects.

There is an imperative need to identify previously unconsidered mechanisms for successful modulation of therapeutic response in this aggressive subtype of breast cancer.

We reported that the desired plasma concentration of selenium for optimal modulation of the therapeutic efficacy and selectivity of anticancer drugs in preclinical models is 20 30  μ M (Fakih et al, 2006; Azrak et al, 2007), and this can be achieved by oral administration of SLM, twice daily, for 7 days at 7200  μg per patient without toxicity (Fakih et al, 2008).

This method combines the advantages of stem cell and gene therapy together: Regeneration of functional neural tissue by stem cells and modulation of pathophysiology by therapeutic genes.

Our finding that Nodal signaling is maternally regulated by translational repression could allow modulation of these important therapeutic cells by this new mechanism.

Nevertheless, since these peptides upregulate autophagy and influence the outcome of rhabdoviral infections, G glycoproteins should be the target of future studies oriented at the modulation of autophagy for therapeutic purposes.

Secondly, in order to elucidate the potential modulation of fascin by therapeutic intervention and the subsequent consequences for epithelial repair, we studied the effects of 5-ASA and sodium butyrate on fascin expression and cell motility using an in vitro cell line model.

A comprehensive understanding of mGluR5 regulation in major depression, particularly in comparison to schizophrenia, is crucial as this has extensive implications for mGluR5 targeting novel therapeutics, especially considering that opposing modulation of mGluR5 is of therapeutic interest for these two disorders.