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Modulation of drug transporters via herbal medicines which have been widely used in combination with conventional prescription drugs may result in herb drug interactions in clinical practice.
The presence of metallic NPs in the lipid bilayer reinforced bilayer retention and offered a nanoparticle concentration-dependent modulation of drug release in response to external heating.
Their use as drug delivery system is an emerging platform in the field of pharmaceuticals and now-a-days formulation scientists are paying great attention to the technology due to several advantages prime being easy modulation of drug release profile depending upon the properties of polymer/polymeric blends/other materials used.
The addition of hyaluronic acid dressings decreased the hydration properties of the dressing and lead to a modulation of drug release (Rossi et al. 2007).
During the recent years, nucleic acid (DNA, miRNA, siRNA, etc).-based nanoparticles are used as a potential tool in the modulation of drug resistance in tumors, effectively decreasing P-gp/MDR1 expression in vivo.
The potentially most promising avenue for increasing the efficacy of Temozolomide is through modulation of drug resistance.
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Metabolism in brain specific nuclei may play a role in pharmacological modulation of drugs acting on the CNS and help explain some of the diverse response to these drugs seen in patient population.
As cisplatin activity is related to induction of apoptosis, the modulation of drug-induced apoptosis by lonidamine was investigated.
A drug-loaded hydrogel composed of reduced GO and poly vinyl alcohol) enabled on-demand control of dosing via modulation of drug-release rate with the application of an external electric field.
To study the molecular mechanisms responsible for the interaction between gefitinib and Ln-5, we analysed the modulation of drug-specific cell targets such as EGFR, as well as the main steps of its signal transduction pathways, including Erk1/2 and Akt.
This logical approach to the modulation of drug-induced apoptosis is exactly what was hoped would arise from an understanding of cell death, illustrating well the principle that apoptosis results from either loss of survival signals (provided in this setting by ERKs) or death signals (in the present study from JNK).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com