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Our data suggest that inherited variation in MSL1 may impact risk of invasive serous ovarian cancer and are consistent with findings that irregular H4 modifications may cause errors in chromatin folding and gene expression and are widespread in cancer phenotypes [21].
We first discuss some of the problems that genetic modifications may cause.
When regional, these modifications may cause chromatin remodeling and silence expression of most genes in these regions.
Therefore, the lack of information on certain histone modifications may cause the poor prediction rate for some TFs.
In addition, epigenetic modifications may cause individual nucleosomes to shift laterally across the DNA, exposing some areas of DNA for transcription and covering others [8].
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Formation of the age-specific, CKm immunoreactive 130 kDa protein suggests that oxidative modification may cause structural changes that lead to aggregation.
These data suggest that the nitrotyrosine modification may cause a significant shift in the elution properties of 3-NT modified CKm.
However, it remains unclear as to what modifications may have caused the generation of the multiple forms.
The first one is the runtime searching algorithm in the whole target space for target selection (target modification) that may cause a high computation cost for real-time synthesizing.
During the surface modification, it may cause leaching of entrapped drug from NPs during overnight incubation period which may lead to reduction in entrapment of drug.
This is yet another example of how modifications in hardware design may cause unexpected problems.
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