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In particular, ARORs containing active histone modifications may function as enhancers, modulating transcription at a distance.
These and other histone modifications may function independently or in concert to regulate overall gene expression.
In general, SUMO modifications may function to modulate protein subcellular localization, protein-protein interactions, or affect other secondary protein modifications.
Previous research has indicated that intragenic DNA methylation, exonic nucleosomes and histone modifications may function together to regulate transcript splicing and gene expression [ 23, 30, 31].
Generally, TGS seems to be more sensitive to chromatin factor deficiencies than PTGS, although recent reports have suggested that certain histone modifications may function in PTGS as well.
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The role of OPN in nephrolithiasis is though some what unclear; due to very high content of aspartic and glutamic residues, OPN is subjected to significant post translational modification, which may function as regulatory switches in promotion or inhibition of mineralization [ 124].
These histone modifications may serve as a binding platform for non-histone proteins, whose activities change chromatin structure and function.
Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progression.
SNI1 is a nuclear protein and it may function via chromatin remodeling through histone modification.
This result suggested that TGF-β may function to maintain articular cartilage strength by regulating posttranslational modifications in ECM proteins.
Chromatin binding proteins may function as histone-modifying enzymes related to certain activator or repressor recruitment modifications.
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