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This suggests that these host cell modifications may contribute to the parasites' survival in the circulation of the human host.
Reversible modifications are thought to be relevant in physiological processes, while non-reversible modifications may contribute to pathological situations and diseases [1].
Although NO's ability to modify biological molecules has proven to be physiologically important, NO-dependent modifications may contribute to cell death through S-nitrosylation of proteins or the formation of peroxynitrite.
Among parasite-secreted proteins, several types of enzymes (like kinases, several still uncharacterized and phosphatases) are trafficked to the erythrocyte membrane indicating that post-translational modifications may contribute to establish successful intracellular parasite proliferation [6].
These modifications may contribute to explain the lower plasma insulin and pancreatic insulin content observed in LP pups [11] as well as the 3 fold-higher apoptotic rate in islets from offspring of dams fed a low protein diet during early life [17].
The authors suggested that histone modifications may contribute to the pathogenesis of prefrontal dysfunction in schizophrenia.
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The finding that TGFβ decreases SnoN sumoylation suggested that this modification may contribute to SnoN's ability to inhibit EMT.
Both of these talks gave supporting evidence that defects in chromatin modification may contribute to a number of human malignancies.
Thus, decreased vitellogenin protein accumulation and reduced AGE modification may contribute to extended longevity imparted by RIF.
As p53Ser20P is known to interfere with p53 binding to MDM2, it is possible that this modification may contribute to the PERP-related increased p53 accumulation.
In a recent study, the investigators suggested that both DNA methylation and histone modification may contribute to excessive synthesis of extracellular matrix proteins in SSc and that an imbalance may lead to autoimmune diseases and also cancer [ 46].
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