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Exact(5)
Many more such modifications may exist and it will be interesting to examine if any are affected in CIN tumor cells.
Different histone tail modifications may exist.
Theoretically, changes in so far unknown regulatory elements acting at the IGF2/ H19 locus in addition to ICR1 methylation, including other chromatin modifications, may exist in SRS patients.
Initially, it was believed that histone methylation may be irreversible, despite early biochemical work suggesting that enzymatic activities that remove these modifications may exist in cells [ 4, 5].
Thus, the prevalent mechanisms underlying chromatin closing do not appear to extensively rely on known chromatin marks, indicating that yet unknown chromatin compaction-related modifications may exist - or perhaps that "closed" is the default state of unmodified chromatin (note that abundant DNA methylation is lacking in Drosophila, hence it has little direct contribution to chromatin structure).
Similar(54)
Although a substantial effect of this SNP can be excluded, small risk modifications may still exist, which should be investigated in future meta-analyses.
However, a structural modification or surface functionalization may exist during CF4 plasma treatment [14, 16, 17], even though they cannot be detected by normal optical microscopy.
In fact, there may exist some modifications of the wobble rule.
The charge of p53 from differentiated cells was also altered upon phosphatase treatment although no p53 with a pI beyond 8.6 was detected, indicating that additional modifications with a negative charge may exist in differentiated cells.
Therefore, a role may exist for dietary modification to alter BML natural history.
The increased SUR2 level in the I group, however, implies that other PTMs for SUR2 modifications may co-exist.
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