No one knows what those modifications may be.
The modifications may be achieved by passive stiffnesses or by active control techniques.
In patients with mild symptoms of heartburn or regurgitation, simple lifestyle modifications may be effective in producing symptom relief.
Lifestyle modifications may be effective in reducing or eliminating GERD symptoms, but the majority of patients require pharmacologic therapy.
However, a developmental reversion of these modifications may be observed throughout two successive generations.
The same approach, with opportune modifications, may be also applied as healing strategy for a wide set of viruses infections.
A set of design rules define a priori which modifications may be incorporated into the trial design.
These protocols should serve as guidelines only, and modifications may be necessary based on graft selection, presence of articular cartilage involvement, and surgeon preference.
Therefore, designers need to be aware that the behavioural effects induced by different design modifications may be overestimated when using paper prototypes.
In addition, modifications may be included to meet the needs of aged or disabled patients who have cognitive deficits or low literacy skills.
Because most epigenetic modifications may be reversible, DNA methylation and histone deacetylase inhibitors can be used to induce reexpression of genes that have been silenced epigenetically.
