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Identification of stable epigenetic modifications may aid the exploration of genotype-phenotype interactions in complex diseases.
Well-characterized histone modifications may aid in the future in the diagnosis and treatment of a variety of cancers or other disease states.
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Further studies using circular dichroism mass spectrometry will be required to compare these two forms of survivin to define differences in structure and or posttranslational modifications that may aid survivin in binding with its yet to be defined receptor or trafficking proteins.
We have also shown that ChIP-seq of histone modifications and TFs may aid identification of functional SNPs in regions associated to disease found in GWAS.
Regular physical activity is known to improve peripheral insulin sensitivity [ 6] and, in non-pregnant adults, increasing insulin sensitivity through lifestyle modification improves glucose tolerance and may aid in preserving β-cell function [ 7].
The presence of SUMO interaction motifs (SIMs) on other proteins provides surfaces for direct noncovalent interaction with SUMOylated proteins or may aid SUMO modification of the protein (Desterro et al. 1999; Sampson et al. 2001; Kerscher 2007; Zhu et al. 2008).
A few snoRNAs, including U3 and U17/snR30, do not direct modification but are important for rRNA processing and may aid rRNA folding (Hughes, 1996; Fayet-Lebaron et al, 2009).
These genes and pathways may serve as candidate biomarkers and therapeutic targets for poor response and may aid in early and real-time modification of the treatment protocol to improve clinical outcomes.
This information may aid in designing appropriate intervention strategies and planning modifications in the medical curricula to enhance the students' learning abilities.
This protocol may aid in identifying additional species of Archaea and in monitoring modifications in the archaeal flora under various physiological, pathological, and therapeutic circumstances.
These findings may aid in elucidating small RNAs contribute significantly to different phenotypes through epigenetic modification during reciprocal crossing.
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