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Hence, the resulting structural modifications may explain the physical and rheological properties of asphalt during the ageing.
Furthermore the different position of maspin inside the cell or its epigenetic modifications may explain the different behavior of the expression of maspin between tumors.
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DSCAM has been proposed to contribute to the congenital heart disease feature of DS, and it is possible that mis-regulation of a large number of adhesion-related genes through epigenetic modification may explain the increased risk in the DS population [ 45].
And technological change may explain why.
The goal is either to reveal patterns that may be shared by many sequences, or identify modifications that may explain functional and phenotypic variability.
[ 15, 23- 28, 30, 31] Objectively, our technique identifies 2 key points that are different from the traditional Weaver-Dunn modifications, that may explain the better results.
Epimerization leads to no change in mass and it is significantly more difficult to detect than the other post-translational modifications (PTMs) listed above, which may explain why epimerization has received significantly less attention.
At least two potential mechanisms may explain this modification of the self-reactive repertoire observed.
If this effect modification is true then it may explain, at least in part, the nonsignificant results in the studies restricted to women aged under 40 years [ 64].
However, these data contradict reports from genetic studies suggesting that kinase catalytic activity per se may not be required for IPP complex function (reviewed by Wickström et al., 2010 [ 35]. It is possible that ILK gains activity under very specific conditions (e.g. upon post-translational modification and/or allosteric activators), which may explain these contradictory reports.
However, we cannot exclude that in combination with transcriptomic alterations driven by epigenetic histone modifications also acetylation of nonhistone proteins may explain the observed phenotypes.
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