Therefore, it can be assumed that the sub-networks represent the clusters of signalling components, which upon alteration may cause T2D and its associated complications.
In the next paragraph we will discuss the role of p53 family and the detrimental effect(s) that its alteration may cause in NB.
DNA binding activity to these sites was markedly increased in tumoral tissue compared to normal tissue, suggesting that this alteration may cause reduced promoter activity of the Na+/I- symporter gene and determine I- uptake deficiency in human thyroid tumors.
Overall current FLT3 receptor molecular tests provide no information about the functional consequences of these mutations on intracellular signaling pathways and do not detect the presence of other functionally related mutations or alterations that may cause deregulation of FLT3 receptor pathway activity.
These factors may generate lumen alterations which may cause fetal and neonatal complications, such as heart failure, hydrops, neonatal pulmonary hypertension, and even death.
These factors may generate lumen alterations which may cause fetal and neonatal complications, such as heart failure, hydrops, neonatal pulmonary hypertension, and even death (Tarcan et al., 2004; Abdel Mohsen and Amin, 2013; Babaoglu et al., 2013).
We dispensed with using a muscle flap, and this alteration may have caused a lower severity of infections.
The CD15-positive fragments occupied the intercellular matrix, thus suggesting that the alteration may have caused the subversion of normal membrane disposition.
Any uncertainties in the chemical or physical composition of the asphalt or in its alteration status may cause erroneous results.
During tumorigenesis, the hypoxic microenvironment and/or genetic alteration pVHL may cause a high level of HIF-1α in cancer cells [7], [8], suggesting that HIF-1α is a potential target in tumor therapy.
