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The association of cofilin and HSC70 under oxidative stress could be important for the mitochondrial import of cofilin since HSC70 can chaperon mitochondrial import.
HSC70 has been identified as one chaperone that is important for the mitochondrial import.
Our results suggest that HSP90-mediated mitochondrial import of PKCε plays an important role in the protection of the myocardium from IR injury.
The mitochondrial import and assembly (MIA) pathway plays a vitally important role in import and oxidative folding of the mitochondrial intermembrane space (IMS) proteins.
In conclusion, we demonstrate that adenosine induces HSP90-dependent translocation of PKCε to mitochondria, possibly through mitochondrial import machinery TOM70.
Unlike other mitochondrial proteins, the N-terminal signal sequence of 3βHSD2 is not cleaved upon mitochondrial import.
Moreover, truncated leader sequences, retaining the second and/or the third putative α-helix, failed to restore the mitochondrial import of hGDH2.
Mitochondrial proteins such as cytochrome C and mitochondrial import stimulation factor are the primary targets for inactivation by ONOO− which results in mitochondrial oxidative stress [6].
Removal of 20 residues from the dTP of ProRS abolished chloroplastic import, indicating that the N-terminal region was required for chloroplast targeting, whereas deletion of 16 N-terminal amino acids from AspRS-dTP inhibited the mitochondrial import, showing that in this case, the N-terminal portion was required for the mitochondrial import.
How does the nuclear fraction of RNase ZL escape the mitochondrial import pathway?
As for mitochondrial import receptor (AN NP_064628.1) the only theoretical deamidation site is Asn124Thr.
Related(20)
mitochondrial count
mitochondrial product
mitochondrial exporter
mitochondrial importer
mitochondrial amount
mitochondrial transit
mitochondrial entry
mitochondrial insert
mitochondrial production
mitochondrial insertion
mitochondrial supply
mitochondrial transport
mitochondrial entrance
mitochondrial imported
mitochondrial glutathione
mitochondrial spindle
mitochondrial genome
mitochondrial fission
mitochondrial electron
mitochondrial creatine
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