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Yet, what appears here as a defect of the kinetoplast maintenance is again likely one indirect effect secondary to the mis-processing of one mitochondrial imported protein among many.
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The association of cofilin and HSC70 under oxidative stress could be important for the mitochondrial import of cofilin since HSC70 can chaperon mitochondrial import.
HSC70 has been identified as one chaperone that is important for the mitochondrial import.
Our results suggest that HSP90-mediated mitochondrial import of PKCε plays an important role in the protection of the myocardium from IR injury.
The mitochondrial import and assembly (MIA) pathway plays a vitally important role in import and oxidative folding of the mitochondrial intermembrane space (IMS) proteins.
Becker, T. et al. The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins.
CPT-1 is required for mitochondrial import of long-chain fatty acids to initiate β-oxidation.
Qiu, J. et al. Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation.
Unlike other mitochondrial proteins, the N-terminal signal sequence of 3βHSD2 is not cleaved upon mitochondrial import.
Part of this protection afforded by HSP90 is downstream of GSK3β, potentially via the HSP-TOM mitochondrial import pathway.
Klein, J. M. & Schwarz, G. Cofactor-dependent maturation of mammalian sulfite oxidase links two mitochondrial import pathways.
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