Sentence examples for mitochondrial exporter from inspiring English sources
Specifically, it was proposed that the mitochondrial exporter Atm1 exported either fully formed Fe-S clusters or a special form of sulfur that was required for cytosolic Fe-S cluster biogenesis (Lill, 2009), and that loss of Atm1 transporter activity led to the accumulation of iron within the mitochondrial matrix.
Because Leu1 activity was assessed as being low in Atm1-null strains, this was misinterpreted as evidence that the mitochondrial exporter, Atm1, contributed an essential component to cytosolic Fe-S cluster biogenesis.
Chiabrando, D. et al. The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation.
On the other hand, treatment with mitochondrial calcium exporter inhibitor CGP-37157 suppressed cytosolic calcium level.
Two major subgroups are usually recognized: HMT (heavy metal tolerance) and MPE (mitochondrial peptide exporter).
Recent studies have revealed that the mitochondrial heme exporter FLVCR1b, which contains shortened N-terminus resulting from an alternative transcriptional start site (in contrast to originally identified FLVCR1a), is essential for erythroid differentiation [ 34].
Some of the synthesized heme must be exported out of mitochondrion to the cytosolic/nuclear compartment to provide heme cofactors to nonmitochondrial proteins such as guanylate cyclase, but a mitochondrial heme exporter has not yet been identified.
Increased mRNA levels of the isocitrate dehydrogenase 1 (Idh1) and the citrate exporter in the inner mitochondrial membrane (Slc25a1) may indicate a simultaneous increase in citric acid cycle activity and enhanced delivery of acetyl-CoA for cytosolic cholesterol synthesis.
ABCB10 is considered a putative heme exporter and is also located on the mitochondrial inner membrane as a homodimer.
Upregulation of FTMT (mitochondrial ferritin) was accompanied by downregulation of the mitochondrial iron exporter frataxin in initial lesions, suggestive of iron-related mitochondrial injury 31 in early MS lesions.
However, recently another contributing factor has also been identified, because it appears that mitochondrial iron overload causes oxidative stress which leads to activation of genes that combat oxidative stress, including expression of the iron exporter ferroportin (32).
