Sentence examples for mitochondrial importer from inspiring English sources
Indeed, the level of transcriptional expression of the mitochondrial importer, mitoferrin, is increased in a Friedreich's ataxia model (54).
Our data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts.
A recent paper in BMC Developmental Biology reports that a mitochondrial iron importer is required for Drosophila male fertility and normal mitochondrial shaping in spermatids.
In support of this idea, transcriptional expression of the mitochondrial iron importer mitoferrin is increased in frataxin-deficient mouse hearts (Huang et al., 2009).
Metzendorf and Lind characterized D. melanogaster mitoferrin (dmfrn) mutants and showed that the Dmfrn mitochondrial iron importer is required for spermatid mitochondrial morphogenesis and thus for development of mature motile sperm [ 2].
Metzendorf and Lind's identification of a role for the mitochondrial iron importer dmfrn in Drosophila sperm development, and their confirmation of testis expression of other proteins involved in iron homeostasis, set the stage for future exploration of iron metabolism as an important factor in mitochondrial morphogenesis and fertility in both vertebrates and invertebrates.
(Importer: Palm Bay Imports, Boca Raton, Fla).
Mitoferrin-1 functions as an essential importer of iron for the mitochondrial haeme and iron sulphur cluster in erythroblasts and is necessary for erythropoiesis [ 58].
Abundant SLC25A37 encodes mitoferrin-1, an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters in erythroblasts [ 21], and FLT encodes the ferritin light chain, a major component of intracellular iron storage [ 22].
The mitochondrial carrier protein SLC25A38 is the putative glycine importer (81).
However, we and others have failed to detect a mitochondrial targeting sequence in TDP1, suggesting the presence of novel importers or a specific mitochondrial isoform.
