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The uniqueness of the interaction with PYL8 (and with no other PYL) provides an example of receptor specificity - an ABA receptor mediating a specific sub-network of responses.
Since most networks mediating a specific biological function consist of multiple TFs and their- sometimes overlapping- TGs, the capacity to detect TGs genome-wide and in silico with high accuracy would bring major advantages.
This analysis demonstrates how His kinase activity involving a subset of the receptors can play a role in mediating a specific physiological response.
In function, mediating a specific adaptation to desiccation stress, halomucin resembles the mucous cocoon of lungfish that can escape dehydration for several years outside the water.
Possible mechanisms mediating a specific downregulation of these structures in hypoxic tumour areas are of great interest, as numerous studies have demonstrated a significant prognostic importance of hypoxia and hypoxia-associated proteome changes.
E1 activates and links free ubiquitins that will be transferred to one of the E2 enzymes, while at the same time E3 ligase enzymes promote ubiquitylation by mediating a specific interaction between E2 enzymes and the target protein [ 8].
Similar(53)
Our data indicate that Sec15 mediates a specific vesicle trafficking event to ensure proper neuronal fate specification in Drosophila.
In the case of ETS1 and ETS2, for example, the structure of the pointed domain can mediate a specific ERK2 interaction [ 52], consistent with the ERK2 specificity we observed in Figure 1.
These clones displayed a CD4+CD8dim+ (TC5) and CD4+ CD8– (TC7) phenotype and mediated a specific major histocompatibility complex class I-restricted cytotoxic activity toward Cou-LB autologous tumor cell line.
CEM/VM-1 harbors a mutated topoisomerase II gene which mediates a specific resistance to topoisomerase II inhibitors, but not general multidrug resistance [19], [20].
However, it remains unclear if ICP0 mediates a specific function in the cytoplasm of HSV-1 infected cells, or if ICP0 translocates to the cytoplasm for the sole purpose of its incorporation into HSV-1 virions [26], [27], [28], [29].
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