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These clones displayed a CD4+CD8dim+ (TC5) and CD4+ CD8– (TC7) phenotype and mediated a specific major histocompatibility complex class I-restricted cytotoxic activity toward Cou-LB autologous tumor cell line.
As shown by western blot analysis, the chosen siRNA mediated a specific knockdown of the targeted Rel subunit without effects on one of the other subunits.
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The uniqueness of the interaction with PYL8 (and with no other PYL) provides an example of receptor specificity - an ABA receptor mediating a specific sub-network of responses.
Our data indicate that Sec15 mediates a specific vesicle trafficking event to ensure proper neuronal fate specification in Drosophila.
In the case of ETS1 and ETS2, for example, the structure of the pointed domain can mediate a specific ERK2 interaction [ 52], consistent with the ERK2 specificity we observed in Figure 1.
CEM/VM-1 harbors a mutated topoisomerase II gene which mediates a specific resistance to topoisomerase II inhibitors, but not general multidrug resistance [19], [20].
Since most networks mediating a specific biological function consist of multiple TFs and their- sometimes overlapping- TGs, the capacity to detect TGs genome-wide and in silico with high accuracy would bring major advantages.
However, it remains unclear if ICP0 mediates a specific function in the cytoplasm of HSV-1 infected cells, or if ICP0 translocates to the cytoplasm for the sole purpose of its incorporation into HSV-1 virions [26], [27], [28], [29].
In addition, although the complete role of Tetherin in mammals remains unclear, limited data show that Tetherin can (at least) mediate a specific feedback mechanism to turn off interferon production by plasmacytoid dendritic cells [8], [47].
We also begin the discussion on how a generalist odorant receptor may mediate a specific pheromone response.
Each subset of genes, whose regulated expression mediates a specific biological effect of PCFS4, shares a common cis-element.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com