More recent studies have demonstrated roles for miR-539 and miR-381 in mediating a novel regulatory pathway between KIT and microphthalmia-associated transcription factor in normal and malignant mast cells [ 17].
Observations suggest that the propeptide is a key functional domain of ADAMTS9, mediating an unusual regulatory mechanism that may have evolved to ensure maximal activity of this protease at the cell surface.
Together, these data suggest that miR-308 is sufficient to mediate a negative regulatory mechanism controlling dMyc in vivo.
Our results indicate clearly that the transcriptional activity mediated by a regulatory DNA motif is strongly dependent on the distance of this motif from the TSS.
Furthermore, they demonstrate that heme repression of PrrH is mediated by a regulatory mechanism that is distinct from heme-dependent regulation of the PrrF RNAs.
The difference between fermentative and aerobic growth is in part mediated by a regulatory mechanism called glucose repression [ 10- 13].
One possibility is that this is mediated through a regulatory negative feedback network that is a common feature of many signal transduction pathways.
Taken together with those results, late transcriptional regulation in MCF-7 cells is mediated by a regulatory complex containing c-FOS, FRA-1 and FHL2.
For example, the main mechanism may be mediated by a regulatory RNA, which may be neither represented in the network, nor in the expression data gained by microarray experiments.
