Sentence examples for mediating a systemic from inspiring English sources

An evolving model of pregnancy-associated immune changes suggests that the hormonal environment of pregnancy contributes to local suppression of cell-mediated immunity at the maternal-fetal interface while mediating a systemic change toward Th2 dominance.

In aphid, except the existence of SID-1 which is a multispan transmembrane protein mediating a systemic RNAi effect, the uptake mechanism of dsRNA remains to be determined [ 12, 21].

The microemulsion delivery mechanism is likely to mediate a systemic distribution of P42-TAT in the whole organism.

5 MSCs mediate a systemic immunosuppression and have been tested in the treatment of immune disorders such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, and diabetes in several preclinical and clinical studies.

This favours the premise that the reduction in neoplasia seen in the present study is mediated through a systemic effect.

Thus, the anti-cancer effects of metformin are mediated through a systemic improvement in metabolic profile and by directly targeting tumor cells [ 11, 12].

Thus, the anticancer effects of metformin are mediated through a systemic improvement in the metabolic profile and by directly targeting tumor cells [ 10].

Among the proposed hypotheses are hypoxemia and/or hypoperfusion due to pulmonary dysfunction and circulatory depression [ 13] or damage mediated by a systemic inflammatory response induced by the pneumonitis [ 14].

Katayama fever is thought to be mediated by a systemic hypersensitivity reaction to migrating parasites and circulating immune complexes at the onset of egg production [ 4], leading to the classical clinical symptoms.

Based on our in vivo studies, we suggest the following model (Fig. 6): in a first line of defence antiviral and Th1 inducing cytokines are produced that mediate a systemic antiviral milieu and activate NK cells.

However, in our study, we found that intravenous administration of AAV9 mediated a far more systemic transduction of epithelia.