Sentence examples for mediate cellular senescence from inspiring English sources

Alternative rationale may place p53 elsewhere from SirT1 activity in a cellular context to mediate cellular senescence.

In addition to the cell-cycle control, p21 can play either anti- or pro-apoptotic roles in cells and also mediate cellular senescence [74].

Mechanisms for nuclear p53 that mediate cellular senescence are largely known, however, the biochemical role of p53 in other organelle systems is less understood.

However, it is not clear whether a specific microRNA can mediate cellular senescence [ 12].

Therefore, the derepression of p21 and p16 caused by loss of AP4 is sufficient to mediate cellular senescence.

Furthermore, p38/PRAK could activate p53 in response to oncogenic Ras to mediate cellular senescence (Sun et al., 2007).

In conclusion, this presentation clearly showed that glucose restriction mediates its effects by epigenetic regulation via hTERT and p16, thereby extending the cellular lifespan of normal cells or mediating cellular senescence by induction of apoptosis in precancerous cells.

Interestingly, the decrease in miR-29 expression in diseased brains contrasts with the increase in miR-29 expression levels in other tissues during aging and the described role of miR-29 in mediating cellular senescence (see chapter 3).

Further, its role in mediating cellular senescence in settings of extended cell proliferation in vitro (Alcorta et al., 1996), oncogene activation (Serrano et al., 1997), and DNA damage (Schmitt et al., 2002) adds to its appeal as a potential effector of aging.

Intriguingly, we observed CIMP-dependent DNA hypermethylation and transcriptional inactivation of IGFBP7, which has been shown to mediate BRAFV600E-induced cellular senescence and apoptosis [34].

Furthermore, we identified CIMP-dependent DNA hypermethylation of IGFBP7, which has been shown to mediate BRAFV600E-induced cellular senescence and apoptosis.