Reactive oxygen species mediate cellular signaling and neuropathologies.
G-protein coupled receptors (GPCRs), the largest family of human membrane proteins, mediate cellular signaling and represent primary targets of about one third of currently marketed drugs.
At the cellular level, the Salt Overly Sensitive (SOS) signaling pathway that comprises SOS3, SOS2, and SOS1 has been proposed to mediate cellular signaling under salt stress, to maintain ion homeostasis.
Receptor tyrosine kinases (RTKs), which contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain, mediate cellular signal transduction by extracellular ligand binding.
This approach found upregulation of three kinases that mediate cellular signaling in response to BVDV, such as urokinase-type plasminogen activator receptor (u-PAR), myristoilated alanine-rich C kinase substrate (MARCKS), and nucleoside diphosphate kinase B (NDPKB).
TRAF4 is a proapoptotic gene member of the TRAF family of adaptor proteins that mediate cellular signaling by binding to various members of the tumor necrosis family receptor superfamily and interleukin-1/Toll-like receptor superfamily [ 37].
It binds retinoic acid, which mediates cellular signalling in embryonic morphogenesis, and cell growth and differentiation.
I was very proud when [my first graduate student] was awarded the National Science Foundation's East Asia and Pacific Summer Institutes for U.S. Graduate Students award to spend the summer of 2005 in Japan working on Arabidopsis RACK1-mediated cellular signal transductions pathways.
In the present study, we report that Fe-SP in NB cells induced sustained activation of p38 and JNK, two MAPK mediating cellular signaling pathways in response to inflammatory cytokines, UV light, pro-apoptotic stimuli or cytotoxic drugs.
